Functional electrical stimulation-assisted cycle ergometry in the critically ill: protocol for a randomized controlled trial
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F19%3AN0000119" target="_blank" >RIV/00064173:_____/19:N0000119 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/19:43919424
Result on the web
<a href="https://doi.org/10.1186/s13063-019-3745-1" target="_blank" >https://doi.org/10.1186/s13063-019-3745-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s13063-019-3745-1" target="_blank" >10.1186/s13063-019-3745-1</a>
Alternative languages
Result language
angličtina
Original language name
Functional electrical stimulation-assisted cycle ergometry in the critically ill: protocol for a randomized controlled trial
Original language description
BACKGROUND: Intensive care unit (ICU)-acquired weakness is the most important cause of failed functional outcome in survivors of critical care. Most damage occurs during the first week when patients are not cooperative enough with conventional rehabilitation. Functional electrical stimulation-assisted cycle ergometry (FES-CE) applied within 48 h of ICU admission may improve muscle function and long-term outcome. METHODS: An assessor-blinded, pragmatic, single-centre randomized controlled trial will be performed. Adults (n = 150) mechanically ventilated for < 48 h from four ICUs who are estimated to need > 7 days of critical care will be randomized (1:1) to receive either standard of care or FES-CE-based intensified rehabilitation, which will continue until ICU discharge. PRIMARY OUTCOME: quality of life measured by 36-Item Short Form Health Survey score at 6 months. SECONDARY OUTCOMES: functional performance at ICU discharge, muscle mass (vastus ultrasound, N-balance) and function (Medical Research Council score, insulin sensitivity). In a subgroup (n = 30) we will assess insulin sensitivity and perform skeletal muscle biopsies to look at mitochondrial function, fibre typing and regulatory protein expression. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02864745. Registered on 12 August 2016.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30221 - Critical care medicine and Emergency medicine
Result continuities
Project
<a href="/en/project/NV16-28663A" target="_blank" >NV16-28663A: Functional electrical stimulation-assisted cycle ergometry in critically ill: Linking deranged muscle physiology to long-term functional outcome</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Trials
ISSN
1745-6215
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
December
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
Article 724
UT code for WoS article
000506887300003
EID of the result in the Scopus database
2-s2.0-85076679416