Gastric cancer during pregnancy: a report on 13 cases and review of the literature with focus on chemotherapy during pregnancy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F19%3AN0000157" target="_blank" >RIV/00064173:_____/19:N0000157 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/20:43918759
Result on the web
<a href="https://doi.org/10.1111/aogs.13731" target="_blank" >https://doi.org/10.1111/aogs.13731</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/aogs.13731" target="_blank" >10.1111/aogs.13731</a>
Alternative languages
Result language
angličtina
Original language name
Gastric cancer during pregnancy: a report on 13 cases and review of the literature with focus on chemotherapy during pregnancy
Original language description
INTRODUCTION: Gastric cancer during pregnancy is extremely rare and data on optimal treatment and possible chemotherapeutic regimens are scarce. The aim of this study is to describe the obstetric and maternal outcome of patients suffering from gastric cancer during pregnancy and review the literature on antenatal chemotherapy for gastric cancer. MATERIAL AND METHODS: Treatment and outcome of patients registered in the International Network on Cancer, Infertility and Pregnancy (INCIP) database with gastric cancer diagnosed during pregnancy were analyzed. RESULTS: In total, 13 patients with gastric cancer during pregnancy were registered between 2002 and 2018. Median gestational age at diagnosis was 22 weeks (range 6 - 30 weeks). Twelve patients were diagnosed with advanced disease and deceased within 2 years after pregnancy, the majority even within 6 months. In total, 8 out of 10 live births ended in a preterm delivery because of pre-eclampsia, maternal deterioration or therapy planning. Two out of six patients that initiated chemotherapy during pregnancy delivered at term. Two neonates prenatally exposed to chemotherapy were growth restricted and one of them developed a systemic infection with brain abscess after preterm delivery for pre-eclampsia two weeks after chemotherapy. No malformations were reported. CONCLUSIONS: The prognosis of gastric cancer during pregnancy is poor, mainly due to advanced disease at diagnosis, emphasizing the need for early diagnosis. Antenatal chemotherapy can be considered in order to reach fetal maturity, taking possible complications as growth restriction, preterm delivery and hematopoietic suppression at birth into account.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30214 - Obstetrics and gynaecology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Obstetricia et Gynecologica Scandinavica
ISSN
0001-6349
e-ISSN
1600-0412
Volume of the periodical
99
Issue of the periodical within the volume
1
Country of publishing house
DK - DENMARK
Number of pages
10
Pages from-to
79-88
UT code for WoS article
000491186800001
EID of the result in the Scopus database
2-s2.0-85074288798