Gastric cancer during pregnancy: a report on 13 cases and review of the literature with focus on chemotherapy during pregnancy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43918759" target="_blank" >RIV/00216208:11120/20:43918759 - isvavai.cz</a>

Alternative codes found

RIV/00064173:_____/19:N0000157

Result on the web

<a href="https://doi.org/10.1111/aogs.13731" target="_blank" >https://doi.org/10.1111/aogs.13731</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/aogs.13731" target="_blank" >10.1111/aogs.13731</a>

Result language

angličtina

Original language name

Gastric cancer during pregnancy: a report on 13 cases and review of the literature with focus on chemotherapy during pregnancy

Original language description

INTRODUCTION: Gastric cancer during pregnancy is extremely rare and data on optimal treatment and possible chemotherapeutic regimens are scarce. The aim of this study is to describe the obstetric and maternal outcome of patients suffering from gastric cancer during pregnancy and review the literature on antenatal chemotherapy for gastric cancer. MATERIAL AND METHODS: Treatment and outcome of patients registered in the International Network on Cancer, Infertility and Pregnancy (INCIP) database with gastric cancer diagnosed during pregnancy were analyzed. RESULTS: In total, 13 patients with gastric cancer during pregnancy were registered between 2002 and 2018. Median gestational age at diagnosis was 22 weeks (range 6 - 30 weeks). Twelve patients were diagnosed with advanced disease and deceased within 2 years after pregnancy, the majority even within 6 months. In total, 8 out of 10 live births ended in a preterm delivery because of pre-eclampsia, maternal deterioration or therapy planning. Two out of six patients that initiated chemotherapy during pregnancy delivered at term. Two neonates prenatally exposed to chemotherapy were growth restricted and one of them developed a systemic infection with brain abscess after preterm delivery for pre-eclampsia two weeks after chemotherapy. No malformations were reported. CONCLUSIONS: The prognosis of gastric cancer during pregnancy is poor, mainly due to advanced disease at diagnosis, emphasizing the need for early diagnosis. Antenatal chemotherapy can be considered in order to reach fetal maturity, taking possible complications as growth restriction, preterm delivery and hematopoietic suppression at birth into account.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30214 - Obstetrics and gynaecology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Obstetricia et Gynecologica Scandinavica

ISSN

0001-6349

e-ISSN

—

Volume of the periodical

99

Issue of the periodical within the volume

1

Country of publishing house

DK - DENMARK

Number of pages

10

Pages from-to

79-88

UT code for WoS article

000491186800001

EID of the result in the Scopus database

2-s2.0-85074288798