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Monitoring of circulating amino acids in patients with pancreatic cancer and cancer cachexia using capillary

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F21%3AN0000193" target="_blank" >RIV/00064173:_____/21:N0000193 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.1002/elps.202100174" target="_blank" >https://doi.org/10.1002/elps.202100174</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/elps.202100174" target="_blank" >10.1002/elps.202100174</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Monitoring of circulating amino acids in patients with pancreatic cancer and cancer cachexia using capillary

  • Original language description

    Branched chain amino acids (BCAAs), alanine and glutamine are determined in human plasma by capillary electrophoresis with contactless conductivity detection (CE/C(4) D). The baseline separation of five amino acids from other plasma components is achieved on the short capillary effective length of 18 cm in 3.2 mol/L acetic acid with addition of 13% v/v methanol as background electrolyte. Migration times range from 2.01 min for valine to 2.84 min for glutamine, and LODs for untreated plasma are in the interval 0.7-0.9 μmol/L. Sample treatment is based on the addition of acetonitrile to only 15 μL of plasma and supernatant is directly subjected to CE/C(4) D. Circulating amino acids are measured in patients with pancreatic cancer and cancer cachexia during oral glucose tolerance test. It is shown that patients with pancreatic cancer and cancer cachexia syndrome exhibit low basal circulating BCAAs and glutamine levels and loss of their insulin-dependent suppression.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

    <a href="/en/project/NV19-01-00101" target="_blank" >NV19-01-00101: Pancreatic cancer: metabolic derangements assiocated with insulin resistance</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Electrophoresis

  • ISSN

    0173-0835

  • e-ISSN

    1522-2683

  • Volume of the periodical

    42

  • Issue of the periodical within the volume

    19

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    7

  • Pages from-to

    1885-1891

  • UT code for WoS article

    000677778400001

  • EID of the result in the Scopus database

    2-s2.0-85110971924