Epidemiology of moderate-to-severe psoriasis: a comparison between psoriasis patients treated with biological agents, conventional systemic drugs and topical agents

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F22%3A43920584" target="_blank" >RIV/00064173:_____/22:43920584 - isvavai.cz</a>

Alternative codes found

RIV/00064211:_____/20:W0000006 RIV/62156489:43110/22:43918460 RIV/00216208:11110/22:10415432 RIV/00216208:11120/22:43920584 and 2 more

Result on the web

<a href="https://doi.org/10.1080/09546634.2020.1826393" target="_blank" >https://doi.org/10.1080/09546634.2020.1826393</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/09546634.2020.1826393" target="_blank" >10.1080/09546634.2020.1826393</a>

Result language

angličtina

Original language name

Epidemiology of moderate-to-severe psoriasis: a comparison between psoriasis patients treated with biological agents, conventional systemic drugs and topical agents

Original language description

INTRODUCTION: Understanding how different comorbidities and epidemiological factors are related to psoriasis severity can help us estimating patients&apos; clinical outcome. AIM: Establish possible prognostic factors of severe psoriasis. METHODS: Three groups of patients were included: 118 were on topical therapy, 83 used conventional systemic drugs and 112 were treated with biological agents. Based of the fact that patients on topical therapy have a lower grade of disease severity than patients treated systemically, we compared a variety of comorbidities and epidemiological parameters between the three groups. RESULTS: Patients treated more aggressively have an increased risk of cardiovascular disease (p = 0.044), suffer more from depression (p = 0.020), hyperuricemia (p = 0.031) and nonspecific non-infectious liver disease (p = 0.005). Male gender (p &lt; 0.001), increased height (p &lt; 0.001), early age of disease onset (p &lt; 0.001), viral upper respiratory infections (p = 0.049) and periods of hormonal changes (p = 0.045) are associated with these therapies. CONCLUSION: Psoriasis severity is directly related to an increased risk of cardiovascular disease, depression, hyperuricemia and nonspecific non-infectious liver disease. Male gender, increased height, early age of disease onset, viral upper respiratory infections and periods of hormonal changes seem to be prognostic of higher degrees of psoriasis severity. We are pioneering the use of increased height and puberty, menopause/andropause as independent prognostic factors of psoriasis severity.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30216 - Dermatology and venereal diseases

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Dermatological Treatment

ISSN

0954-6634

e-ISSN

1471-1753

Volume of the periodical

33

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

1435-1448

UT code for WoS article

000579900300001

EID of the result in the Scopus database

2-s2.0-85093083096