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Epidemiology of moderate-to-severe psoriasis: a comparison between psoriasis patients treated with biological agents, conventional systemic drugs and topical agents

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F20%3AW0000006" target="_blank" >RIV/00064211:_____/20:W0000006 - isvavai.cz</a>

  • Alternative codes found

    RIV/62156489:43110/22:43918460 RIV/00064173:_____/22:43920584 RIV/00216208:11110/22:10415432 RIV/00216208:11120/22:43920584 and 2 more

  • Result on the web

    <a href="https://dx.doi.org/10.1080/09546634.2020.1826393" target="_blank" >https://dx.doi.org/10.1080/09546634.2020.1826393</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1080/09546634.2020.1826393" target="_blank" >10.1080/09546634.2020.1826393</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Epidemiology of moderate-to-severe psoriasis: a comparison between psoriasis patients treated with biological agents, conventional systemic drugs and topical agents

  • Original language description

    Introduction Understanding how different comorbidities and epidemiological factors are related to psoriasis severity can help us estimating patients' clinical outcome. Aim Establish possible prognostic factors of severe psoriasis. Methods Three groups of patients were included: 118 were on topical therapy, 83 used conventional systemic drugs, and 112 were treated with biological agents. Based on the fact that patients on topical therapy have a lower grade of disease severity than patients treated systemically, we compared a variety of comorbidities and epidemiological parameters between the three groups. Results Patients treated more aggressively have an increased risk of cardiovascular disease (p = .044), suffer more from depression (p = .020), hyperuricemia (p = .031) and nonspecific noninfectious liver disease (p = .005). Male gender (p < .001), increased height (p < .001), early age of disease onset (p < .001), viral upper respiratory infections (p = .049) and periods of hormonal changes (p = .045) are associated with these therapies. Conclusion Psoriasis severity is directly related to an increased risk of cardiovascular disease, depression, hyperuricemia and nonspecific noninfectious liver disease. Male gender, increased height, early age of disease onset, viral upper respiratory infections and periods of hormonal changes seem to be prognostic of higher degrees of psoriasis severity. We are pioneering the use of increased height and puberty, menopause/andropause as independent prognostic factors of psoriasis severity.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30216 - Dermatology and venereal diseases

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    JOURNAL OF DERMATOLOGICAL TREATMENT

  • ISSN

    0954-6634

  • e-ISSN

    1471-1753

  • Volume of the periodical

  • Issue of the periodical within the volume

    20 Oct 2020

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    14

  • Pages from-to

    -

  • UT code for WoS article

    000579900300001

  • EID of the result in the Scopus database

    2-s2.0-85093083096