Senescence-Associated miRNAs and Their Role in Pancreatic Cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F22%3A43923549" target="_blank" >RIV/00064173:_____/22:43923549 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/22:43923549
Result on the web
<a href="https://doi.org/10.3389/pore.2022.1610156" target="_blank" >https://doi.org/10.3389/pore.2022.1610156</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/pore.2022.1610156" target="_blank" >10.3389/pore.2022.1610156</a>
Alternative languages
Result language
angličtina
Original language name
Senescence-Associated miRNAs and Their Role in Pancreatic Cancer
Original language description
Replicative senescence is irreversible cell proliferation arrest for somatic cells which can be circumvented in cancers. Cellular senescence is a process, which may play two opposite roles. On the one hand, this is a natural protection of somatic cells against unlimited proliferation and malignant transformation. On the other hand, cellular secretion caused by senescence can stimulate inflammation and proliferation of adjacent cells that may promote malignancy. The main genes controlling the senescence pathways are also well known as tumor suppressors. Almost 140 genes regulate both cellular senescence and cancer pathways. About two thirds of these genes (64%) are regulated by microRNAs. Senescence-associated miRNAs can stimulate cancer progression or act as tumor suppressors. Here we review the role playing by senescence-associated miRNAs in development, diagnostics and treatment of pancreatic cancer.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pathology & Oncology Research
ISSN
1219-4956
e-ISSN
1532-2807
Volume of the periodical
28
Issue of the periodical within the volume
April
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
1610156
UT code for WoS article
000796041400001
EID of the result in the Scopus database
2-s2.0-85130062151