The potential roles of vesicle-enclosed miRNAs in communication between macrophages and cancer cells in tumor microenvironment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10363952" target="_blank" >RIV/00216208:11110/17:10363952 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/17:10363952 RIV/00064165:_____/17:10363952

Result on the web

<a href="http://dx.doi.org/10.4149/neo_2017_311" target="_blank" >http://dx.doi.org/10.4149/neo_2017_311</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2017_311" target="_blank" >10.4149/neo_2017_311</a>

Result language

angličtina

Original language name

The potential roles of vesicle-enclosed miRNAs in communication between macrophages and cancer cells in tumor microenvironment

Original language description

Functional microRNA (miRNA) molecules are transported in extracellular vesicles among tumor cells and cells of the immune system. Macrophages as integral components of tumor microenvironment are known as potential contributors to tumor growth and progression. We searched for studies which could provide a direct link between the particular miRNAs transported between cancer cells and macrophages and experimental evidence of subsequent alterations in biological functions of target cells. The validated targets of such microRNAs were found using miRWalk database. These targets were further subjected to analysis by DAVID (Database for Annotation, Visualization and Integrated Discovery) to find the most prominent cellular events that could be potentially regulated in macrophages by miRNAs originated from cancer cells and vice versa. We found that the 5 miRNAs (let-7b, miR-21, miR-29a, miR-222-3p, miR-451) derived from cancer cells may together regulate 2304 target genes in macrophages. The genes involved in regulation of apoptosis, regulation of gene expression and protein transport were significantly overrepresented in this set. Four of the five sets of target genes for these individual miRNAs overlap in MYC oncogene. MYC dependent transcriptional program is responsible for cell cycle entry and regulates the inflammatory response in macrophages. Both miRNAs for which the functional transports from macrophages to cancer cells were experimental proven (miR-223, miR-142-3p) target total 684 genes including some well-known tumor suppressors like TP53 or APC. Suppression of tumor suppressor genes by miRNAs derived from macrophages may eventually contribute to cancer cell proliferation.Due to the complexity of tumor microenvironment, the altered expression profiles of its components affected by miRNA uptake from extracellular vesicles could contribute to the outcome of carcinogenesis therefore the vesicular transport of miRNAs should be studied more extensively in this context.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10600 - Biological sciences

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

—

Volume of the periodical

64

Issue of the periodical within the volume

3

Country of publishing house

SK - SLOVAKIA

Number of pages

6

Pages from-to

406-411

UT code for WoS article

000402095500011

EID of the result in the Scopus database

2-s2.0-85020445059