The role of microRNA-21 in the onset and progression of cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F21%3A50018386" target="_blank" >RIV/62690094:18470/21:50018386 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/21:10435233 RIV/00179906:_____/21:10435233
Result on the web
<a href="https://www.future-science.com/doi/abs/10.4155/fmc-2021-0096" target="_blank" >https://www.future-science.com/doi/abs/10.4155/fmc-2021-0096</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4155/fmc-2021-0096" target="_blank" >10.4155/fmc-2021-0096</a>

Result language
angličtina
Original language name
The role of microRNA-21 in the onset and progression of cancer
Original language description
MicroRNAs (miRNAs), a class of small noncoding RNA, posttranscriptionally regulate the expression of genes. Aberrant expression of miRNA is reported in various types of cancer. Since the first report of oncomiR-21 involvement in the glioma, its upregulation was reported in multiple cancers and was allied with high oncogenic property. In addition to the downregulation of tumor suppressor genes, the miR-21 is also associated with cancer resistance to various chemotherapy. The recent research is appraising miR-21 as a promising cancer target and biomarker for early cancer detection. In this review, we briefly explain the biogenesis and regulation of miR-21 in cancer cells. Additionally, the review features the assorted genes/pathways regulated by the miR-21 in various cancer and cancer stem cells.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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