MicroRNAs in B cell lymphomas: how a complex biology gets more complex

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F15%3A00082261" target="_blank" >RIV/00216224:14740/15:00082261 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/15:00063595

Result on the web

<a href="http://www.nature.com/leu/journal/v29/n5/pdf/leu2014351a.pdf" target="_blank" >http://www.nature.com/leu/journal/v29/n5/pdf/leu2014351a.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/leu.2014.351" target="_blank" >10.1038/leu.2014.351</a>

Result language

angličtina

Original language name

MicroRNAs in B cell lymphomas: how a complex biology gets more complex

Original language description

MicroRNAs (miRNAs) represent important regulators of gene expression besides transcriptional control. MiRNA regulation can be involved in the cell developmental fate decisions, but can also have more subtle roles in buffering stochastic fluctuations in gene expression. They participate in pathways fundamental to B cell development like B cell receptor (BCR) signalling, B cell migration/adhesion, cell-cell interactions in immune niches, and the production and class-switching of immunoglobulins. MiRNAs influence B cell maturation, generation of pre-, marginal zone, follicular, B1, plasma and memory B cells. In this review, we discuss miRNAs with essential functions in malignant B cell development (such as miR-150, miR-155, miR-21, miR-34a, miR-17-92, miR-15-16). We also put these miRNAs in the context of normal B cell differentiation, since this is intimately connected to neoplastic B cell development.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Leukemia

ISSN

0887-6924

e-ISSN

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Volume of the periodical

29

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

1004-1017

UT code for WoS article

000354070600002

EID of the result in the Scopus database

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