Genetics of migraine: where are we now?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F23%3A43925165" target="_blank" >RIV/00064173:_____/23:43925165 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/23:43925165

Result on the web

<a href="https://doi.org/10.1186/s10194-023-01547-8" target="_blank" >https://doi.org/10.1186/s10194-023-01547-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s10194-023-01547-8" target="_blank" >10.1186/s10194-023-01547-8</a>

Result language

angličtina

Original language name

Genetics of migraine: where are we now?

Original language description

Migraine is a complex brain disorder explained by the interaction of genetic and environmental factors. In monogenic migraines, including familial hemiplegic migraine and migraine with aura associated with hereditary small-vessel disorders, the identified genes code for proteins expressed in neurons, glial cells, or vessels, all of which increase susceptibility to cortical spreading depression. The study of monogenic migraines has shown that the neurovascular unit plays a prominent role in migraine. Genome-wide association studies have identified numerous susceptibility variants that each result in only a small increase in overall migraine risk. The more than 180 known variants belong to several complex networks of &quot;pro-migraine&quot; molecular abnormalities, which are mainly neuronal or vascular. Genetics has also highlighted the importance of shared genetic factors between migraine and its major co-morbidities, including depression and high blood pressure. Further studies are still needed to map all of the susceptibility loci for migraine and then to understand how these genomic variants lead to migraine cell phenotypes.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Headache and Pain

ISSN

1129-2369

e-ISSN

1129-2377

Volume of the periodical

24

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

12

UT code for WoS article

000950598100002

EID of the result in the Scopus database

2-s2.0-85148407564