Quantifying pH-induced changes in plasma strong ion difference during experimental acidosis: clinical implications for base excess interpretation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F24%3A43926939" target="_blank" >RIV/00064173:_____/24:43926939 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/24:43926939
Result on the web
<a href="https://doi.org/10.1152/japplphysiol.00917.2023" target="_blank" >https://doi.org/10.1152/japplphysiol.00917.2023</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1152/japplphysiol.00917.2023" target="_blank" >10.1152/japplphysiol.00917.2023</a>
Alternative languages
Result language
angličtina
Original language name
Quantifying pH-induced changes in plasma strong ion difference during experimental acidosis: clinical implications for base excess interpretation
Original language description
It is commonly assumed that changes in plasma strong ion difference (SID) result in equal changes in whole blood base excess (BE). However, at varying pH, albumin ionic-binding and transerythrocyte shifts alter the SID of plasma without affecting that of whole blood (SIDwb), i.e., the BE. We hypothesize that, during acidosis, 1) an expected plasma SID (SIDexp) reflecting electrolytes redistribution can be predicted from albumin and hemoglobin's charges, and 2) only deviations in SID from SIDexp reflect changes in SIDwb, and therefore, BE. We equilibrated whole blood of 18 healthy subjects (albumin = 4.8 +/- 0.2 g/dL, hemoglobin = 14.2 +/- 0.9 g/dL), 18 septic patients with hypoalbuminemia and anemia (albumin = 3.1 +/- 0.5 g/dL, hemoglobin = 10.4 +/- 0.8 g/dL), and 10 healthy subjects after in vitro-induced isolated anemia (albumin = 5.0 +/- 0.2 g/dL, hemoglobin = 7.0 +/- 0.9 g/dL) with varying CO2 concentrations (2-20%). Plasma SID increased by 12.7 +/- 2.1, 9.3 +/- 1.7, and 7.8 +/- 1.6 mEq/L, respectively (P < 0.01) and its agreement (bias[limits of agreement]) with SIDexp was strong: 0.5[-1.9; 2.8], 0.9[-0.9; 2.6], and 0.3[-1.4; 2.1] mEq/L, respectively. Separately, we added 7.5 or 15 mEq/L of lactic or hydrochloric acid to whole blood of 10 healthy subjects obtaining BE of -6.6 +/- 1.7, -13.4 +/- 2.2, -6.8 +/- 1.8, and -13.6 +/- 2.1 mEq/L, respectively. The agreement between Delta BE and Delta SID was weak (2.6[-1.1; 6.3] mEq/L), worsening with varying CO2 (2-20%): 6.3[-2.7; 15.2] mEq/L. Conversely, Delta SIDwb (the deviation of SID from SIDexp) agreed strongly with Delta BE at both constant and varying CO2: -0.1[-2.0; 1.7], and -0.5[-2.4; 1.5] mEq/L, respectively. We conclude that BE reflects only changes in plasma SID that are not expected from electrolytes redistribution, the latter being predictable from albumin and hemoglobin's charges.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30223 - Anaesthesiology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Applied Physiology
ISSN
8750-7587
e-ISSN
1522-1601
Volume of the periodical
136
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
966-976
UT code for WoS article
001206316800005
EID of the result in the Scopus database
2-s2.0-85190900788