Unique clinical, morphological, and molecular characteristics of tumors associated with PSC-IBD
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F25%3A43928279" target="_blank" >RIV/00064173:_____/25:43928279 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10496262 RIV/00216208:11120/25:43928279 RIV/00216208:11130/25:10496262 RIV/00064203:_____/25:10496262 and 2 more
Result on the web
<a href="https://doi.org/10.1007/s00428-025-04072-y" target="_blank" >https://doi.org/10.1007/s00428-025-04072-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00428-025-04072-y" target="_blank" >10.1007/s00428-025-04072-y</a>
Alternative languages
Result language
angličtina
Original language name
Unique clinical, morphological, and molecular characteristics of tumors associated with PSC-IBD
Original language description
Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease characterized by chronic inflammation and progressive fibrosis of the biliary tree, leading to significant liver function impairment over time. There is a strong association with inflammatory bowel diseases (IBD), together representing a distinct and complex medical condition. Patients with PSC-IBD face a heightened risk of various cancers, particularly colorectal carcinoma (CRC) and cholangiocarcinoma (CCA) as the most common types. In this review, we aim to characterize the distinctive features of PSC-IBD-associated carcinomas. Cancer pathogenesis in PSC-IBD is shaped by various factors including dysregulated bile acid metabolism, gut dysbiosis, and unique immune responses. PSC-IBD-associated CRC is often right-sided and warrants vigilant monitoring due to its higher incidence and unique morphological features compared to CRC arising in the terrain of IBD alone. CCA shares substantial genetic similarities with extrahepatic CCA and poses diagnostic challenges since it is frequently detected at advanced stages due to symptom overlap with PSC. Besides, reliable predictive biomarkers for targeted therapy remain largely unexplored. The distinct molecular, genetic, and histopathological profiles of CRC and CCA in PSC-IBD underscore the complexity of these malignancies and highlight the need for continued research to develop precise therapeutic strategies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Virchows Archiv
ISSN
0945-6317
e-ISSN
1432-2307
Volume of the periodical
486
Issue of the periodical within the volume
4
Country of publishing house
DE - GERMANY
Number of pages
11
Pages from-to
651-661
UT code for WoS article
001448789800001
EID of the result in the Scopus database
2-s2.0-105000310094