The gut microbiome and metabolome in children with a first febrile urinary tract infection: a pilot study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F25%3A43928438" target="_blank" >RIV/00064173:_____/25:43928438 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/25:43928438 RIV/00216208:11130/25:10498029 RIV/00064203:_____/25:10498029
Result on the web
<a href="https://doi.org/10.1007/s00467-025-06782-6" target="_blank" >https://doi.org/10.1007/s00467-025-06782-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00467-025-06782-6" target="_blank" >10.1007/s00467-025-06782-6</a>
Alternative languages
Result language
angličtina
Original language name
The gut microbiome and metabolome in children with a first febrile urinary tract infection: a pilot study
Original language description
BACKGROUND: Urinary tract infection (UTI) is a common bacterial infection in the pediatric population. Febrile urinary tract infection (fUTI) can lead to severe complications such as urosepsis as well as kidney scarring, chronic kidney disease, and systemic hypertension. Recent research supports the hypothesis that dysbiosis of the microbiome may play a role in the pathogenesis and development of fUTI in infants. Our main aim was to compare the shift in gut microbiota composition between children with the first fUTI and controls. METHODS: We conducted an observational study with 17 children with the first fUTI compared to 18 healthy controls. We performed analysis of the gastrointestinal microbiome and measurements of metabolites in stool and urine. RESULTS: In the gut microbiome, we found significant differences with lower α-diversity the Shannon index) and significantly lower relative abundance of probiogenic bacteria (short-chain fatty acids (SCFA)) in children with the first episode of fUTI before the start of antibiotic therapy. Furthermore, our findings confirm that the length of breastfeeding has significant influence on gut microbiota composition, reducing pathogenic bacteria and enhancing beneficial taxa. Shannon diversity, duration of breastfeeding, and specific taxa, particularly Faecalibacterium and Escherichia, emerged as strong predictors linked to the development of fUTI. CONCLUSIONS: This study demonstrates that gut microbiome changes are associated with the onset of fUTI in children. Machine learning models identified Shannon index, specific bacterial taxa, and breastfeeding as strong predictors of fUTI. The study highlighted the potential role of the gut microbiome in preventing fUTI.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pediatric Nephrology
ISSN
0931-041X
e-ISSN
1432-198X
Volume of the periodical
40
Issue of the periodical within the volume
10
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
3145-3154
UT code for WoS article
001488382800001
EID of the result in the Scopus database
2-s2.0-105005113542