The effect of fecal microbial transplantation in a pediatric patient after 28 episodes of febrile urinary tract infection
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F25%3A10498126" target="_blank" >RIV/00064203:_____/25:10498126 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/25:10498126
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=0ib3q9s4KU" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=0ib3q9s4KU</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00467-025-06822-1" target="_blank" >10.1007/s00467-025-06822-1</a>
Alternative languages
Result language
angličtina
Original language name
The effect of fecal microbial transplantation in a pediatric patient after 28 episodes of febrile urinary tract infection
Original language description
Recurrent febrile urinary tract infections (fUTIs) in children can lead to serious complications such as renal scarring and progressive chronic kidney disease (CKD), with growing evidence indicating that gut microbiome dysbiosis may play a key role in their development. Fecal microbial transplantation (FMT) is an established therapeutic approach for restoring gut microbial balance; however, its use in patients with recurrent fUTIs remains limited and underexplored. This case study describes a 10-year-old boy with recurrent fUTIs and CKD secondary to a posterior urethral valve (PUV) anomaly. The patient was administered a total of seven doses of FMT. FMT reduced pathogenic Enterobacteriaceae, increased beneficial short-chain fatty acid (SCFA)-producing genera, and correspondingly raised SCFA levels, indicating restoration of gut microbiota balance. FMT presents an innovative therapeutic option for pediatric patients with recurrent fUTIs, demonstrating outstanding clinical outcomes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pediatric Nephrology
ISSN
0931-041X
e-ISSN
1432-198X
Volume of the periodical
40
Issue of the periodical within the volume
10
Country of publishing house
DE - GERMANY
Number of pages
4
Pages from-to
3085-3088
UT code for WoS article
001491317200001
EID of the result in the Scopus database
2-s2.0-105005798727