Synemin is expressed in reactive astrocytes and Rosenthal fibers in Alexander disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F14%3A%230000844" target="_blank" >RIV/00064190:_____/14:#0000844 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/apm.12088" target="_blank" >http://dx.doi.org/10.1111/apm.12088</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/apm.12088" target="_blank" >10.1111/apm.12088</a>

Result language
angličtina
Original language name
Synemin is expressed in reactive astrocytes and Rosenthal fibers in Alexander disease
Original language description
Alexander disease (AxD) is a neurodegenerative disorder with prominent white matter degeneration and the presence of Rosenthal fibers containing aggregates of glial fibrillary acidic protein (GFAP), and small stress proteins HSP27 and B-crystallin, and widespread reactive gliosis. AxD is caused by mutations in GFAP, the main astrocyte intermediate filament protein. We previously showed that intermediate filament protein synemin is upregulated in reactive astrocytes after neurotrauma. Here, we examined immunohistochemically the presence of synemin in reactive astrocytes and Rosenthal fibers in two patients with AxD. There was an abundance of GFAP-positive Rosenthal fibers and widespread reactive gliosis in the white matter and subpial regions. Many of the GFAP-positive reactive astrocytes were positive for synemin, and synemin was also present in Rosenthal fibers. We show that synemin is expressed in reactive astrocytes in AxD, and is also present in Rosenthal fibers. The potential role
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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