Differential effect of metabolic syndrome on various parameters of arterial stiffness

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F15%3A%230001047" target="_blank" >RIV/00064190:_____/15:#0001047 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/15:10295086 RIV/00216208:11140/15:10295086 RIV/00669806:_____/15:10295086 RIV/00023001:_____/15:00059622

Result on the web

<a href="http://dx.doi.org/10.3109/08037051.2015.1049420" target="_blank" >http://dx.doi.org/10.3109/08037051.2015.1049420</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/08037051.2015.1049420" target="_blank" >10.3109/08037051.2015.1049420</a>

Result language

angličtina

Original language name

Differential effect of metabolic syndrome on various parameters of arterial stiffness

Original language description

Metabolic syndrome (MetSy) is associated with a high risk of cardiovascular complications. Arterial stiffness is an independent predictor of cardiovascular morbidity and mortality. This study investigated the effect of individual MetSy risk factors on central and peripheral parameters of aortic stiffness. In the Czech post-MONICA study, we measured aortic pulse-wave velocity (aPWV), lower extremity pulse-wave velocity (lePWV), augmentation index (AIx) and central augmentation pressure (cAP) in 936 subjects. Based on the definition of MetSy, we divided subjects according to number of risk factors. We used univariate and multivariate linear regression analysis to assess the association between number of risk factors and aPWV, lePWV, AIx and cAP. In analyses adjusted for age, gender, heart rate and mean arterial pressure, aPWV was higher in subjects with MetSy (MetSy + group) than in those without (MetSy - group) (8.3 vs 7.7 m/s; p < 0.0001), but lePWV was not significantly different between the groups (11.0 vs 11.2 m/s; p = 0.2037). After adjustment for covariates, AIx in MetSy + was lower than in MetSy - respondents (143.2 vs 146.8; p - 0.014). In adjusted analysis, aPWV rose with increasing number of MetSy risk factors (7.3 +/- 0.1 vs 9.0 +/- 0.1 m/s; p for trend < 0.0001). The number of MetSy risk factors did not affect lePWV (p = 0.11). AIx decreased with higher number of MetSy risk factors (148.3 vs 141.5; p = 0.020). This finding confirms the fact that PWV and AIx may have different associations with risk factors and AIx should not be used as an isolated parameter of arterial stiffness. The individual MetSy risk factors have only a small effect on lower extremity arterial stiffness.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

<a href="/en/project/ED2.1.00%2F03.0076" target="_blank" >ED2.1.00/03.0076: Biomedical Centre of the Faculty of Medicine in Pilsen</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BLOOD PRESSURE

ISSN

0803-7051

e-ISSN

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Volume of the periodical

24

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

206-21

UT code for WoS article

000359805000002

EID of the result in the Scopus database

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