Soluble receptor for advanced glycation end products and increased aortic stiffness in the general population

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00066073" target="_blank" >RIV/00159816:_____/16:00066073 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11140/16:10323353 RIV/00669806:_____/16:10323353 RIV/00064190:_____/16:N0000039 RIV/00216208:11110/16:10323353

Result on the web

<a href="http://dx.doi.org/10.1038/hr.2015.131" target="_blank" >http://dx.doi.org/10.1038/hr.2015.131</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/hr.2015.131" target="_blank" >10.1038/hr.2015.131</a>

Result language

angličtina

Original language name

Soluble receptor for advanced glycation end products and increased aortic stiffness in the general population

Original language description

It has been suggested that accumulation of advanced glycation end products (AGEs) is involved in several pathophysiological processes in the vessel wall. We hypothesized that low levels of the soluble receptor for AGEs (sRAGE) might be associated with increased arterial stiffness, a manifestation of vascular ageing in the general population. Using a cross-sectional design, we analyzed 1077 subjects from the Czech post-MONICA study. The aortic pulse wave velocity (aPWV) was measured using a Sphygmocor device. sRAGE concentrations were assessed in frozen samples using enzyme-linked immunosorbent assay methods (R&D Systems). aPWV significantly (P<0.0001) increased across the sRAGE quartiles. An aPWV of 1 m s(-1) was associated with a 37% increase in the risk of low sRAGE (<918 pg ml(-1), bottom quartile; P-value 0.018). In a categorized manner, subjects in the bottom sRAGE quartile had an odds ratio of an increased aPWV (}= 9.3m s(-1)), adjusted for all potential confounders of 2.05 (95% confidence interval: 1.26-3.32; P 0.004), but this was only the case for non-diabetic hypertensive patients. In contrast, a low sRAGE was rejected as an independent predictor of an increased aPWV in normotensive or diabetic subjects using similar regression models. In conclusion, low circulating sRAGE was independently associated with increased arterial stiffness in a general population-based sample, but this was only observed in hypertensive non-diabetic patients.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Hypertension Research

ISSN

0916-9636

e-ISSN

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Volume of the periodical

39

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

266-271

UT code for WoS article

000373847300014

EID of the result in the Scopus database

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