The association between low 25-hydroxyvitamin D and increased aortic stiffness

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F12%3A10124201" target="_blank" >RIV/00216208:11140/12:10124201 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/12:10124201 RIV/00064190:_____/12:#0000466
Result on the web
<a href="http://dx.doi.org/10.1038/jhh.2011.94" target="_blank" >http://dx.doi.org/10.1038/jhh.2011.94</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/jhh.2011.94" target="_blank" >10.1038/jhh.2011.94</a>

Result language
angličtina
Original language name
The association between low 25-hydroxyvitamin D and increased aortic stiffness
Original language description
There is accumulating evidence that vitamin D exerts important pathophysiological effects on cardiovascular system. Low vitamin D was associated with increased cardiovascular risk in several reports. We studied the association between vitamin D and arterial stiffness in a random sample of 560 subjects selected from general population. Arterial stiffness was measured as aortic pulse-wave velocity (PWV) using Sphygmocor device. Serum 25-hydroxyvitamin D (25(OH)D) was measured using commercial kits. We found a clear negative trend in aortic PWV among 25(OH)D quartiles. Subjects in the bottom 25(OH)D quartile (<20 ng ml(-1)) showed the highest aortic PWV (9.04 m s(-1)), compared with 2nd-4th quartile (8.07 m s(-1), 7.93 m s(-1) and 7.70 m s(-1), respectively; P for trend <0.0001). The association between 25(OH)D and aortic PWV remained significant after adjustment for age, gender and other potential confounders; subjects in the first 25(OH)D quartile had adjusted odds ratio 2.04 (1.26-3.30
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
—

Project
<a href="/en/project/NT12102" target="_blank" >NT12102: Secondary prevention and prognosis of post-stroke patients</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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