Desphospho-uncarboxylated matrix Gla protein is associated with increased aortic stiffness in a general population

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00063018" target="_blank" >RIV/00159816:_____/16:00063018 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10323747 RIV/00216208:11140/16:10323747 RIV/00669806:_____/16:10323747 RIV/00064190:_____/16:N0000296

Result on the web

<a href="http://dx.doi.org/10.1038/jhh.2015.55" target="_blank" >http://dx.doi.org/10.1038/jhh.2015.55</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/jhh.2015.55" target="_blank" >10.1038/jhh.2015.55</a>

Result language

angličtina

Original language name

Desphospho-uncarboxylated matrix Gla protein is associated with increased aortic stiffness in a general population

Original language description

Matrix Gla protein (MGP), a natural inhibitor of calcification, strongly correlates with the extent of coronary calcification. Vitamin K is the essential cofactor for the activation of MGP. The nonphosphorylated-uncarboxylated isoform of MGP (dp-ucMGP) reflects the status of this vitamin. We investigated whether there is an association between dp-ucMGP and stiffness of elastic and muscular-type large arteries in a random sample from the general population. In a cross-sectional design, we analyzed 1087 subjects from the Czech post-MONICA study. Aortic and femoro-popliteal pulse wave velocities (PWVs) were measured using a Sphygmocor device. Dp-ucMGP concentrations were assessed in freshly frozen samples by enzyme-linked immunosorbent assay methods using the InaKtif MGP iSYS pre-commercial kit developed by IDS and VitaK. Aortic PWV significantly (P<0.0001) increased across the dp-ucMGP quartiles. After adjustment for all potential confounders, aortic PWV independently correlated with dp-ucMGP (with beta coefficient (s.d.) 11.61 (5.38) and P-value=0.031). In a categorized manner, subjects in the top quartile of dp-ucMGP (greater than or equal to 671 pmol lMINUS SIGN 1) had a higher risk of elevated aortic PWV, with corresponding adjusted odds ratio (95% confidence interval) 1.73 (1.17-2.5). In contrast, no relation between dp-ucMGP and femoro-popliteal PWV was found. In conclusion, increased dp-ucMGP, which is a circulating biomarker of vitamin K status and vascular calcification, is independently associated with aortic stiffness, but not with stiffness of distal muscular-type arteries.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Human Hypertension

ISSN

0950-9240

e-ISSN

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Volume of the periodical

30

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

418-423

UT code for WoS article

000377493400003

EID of the result in the Scopus database

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