Influence of Body Fatness Distribution and Total Lean Mass on Aortic Stiffness in Nonobese Individuals

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F15%3A%230001062" target="_blank" >RIV/00064190:_____/15:#0001062 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/15:00061200 RIV/00216208:11110/15:10294979 RIV/00023001:_____/15:00059360

Result on the web

<a href="http://dx.doi.org/10.1093/ajh/hpu153" target="_blank" >http://dx.doi.org/10.1093/ajh/hpu153</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ajh/hpu153" target="_blank" >10.1093/ajh/hpu153</a>

Result language

angličtina

Original language name

Influence of Body Fatness Distribution and Total Lean Mass on Aortic Stiffness in Nonobese Individuals

Original language description

BACKGROUND Subjects with normal body mass index but high body fat percentage have higher cardiovascular risk than subjects with normal weight and low fat mass. However, the association of fat distribution and lean mass with carotid-femoral pulse wave velocity (cfPWV) among nonobese apparently healthy individuals has never been assessed. METHODS In 136 nonobese volunteers (mean age = 45 +/- 9 years; 57% women) without manifest cardiovascular disease, cfPWV was measured by applanation tonometry. Fat and lean mass were measured by dual-energy x-ray absorptiometry. RESULTS In univariate analysis, total fat (r = 0.17; P < 0.01), trunk fat (r = 0.27; P < 0.01), and trunk/total fat ratio (r = 0.32; P < 0.01) were correlated with cfPWV. After adjustment for age and mean arterial pressure, only central fat distribution (trunk/total fat ratio) was significantly associated with cfPWV. In the fully adjustment model, there was a significant interaction between fat distribution and lean mass. When the study sample was grouped by fat distribution and total lean mass medians, subjects with central fat distribution and low lean mass (group 4) had higher log-transformed cfPWV than the noncentral fat/low lean mass group (group 2) (0.89, 95% confidence interval (CI) = 0.86-0.92 vs. 0.85, 95% CI = 0.83-0.87; P < 0.01) or the noncentral fat/high lean mass group (group 1) (0.89, 95% CI = 0.86-0.92 vs. 0.84, 95% CI = 0.81-0.87; P < 0.01) after adjustments. Aortic stiffness increased from group 1 to group 4 (P for linear trend < 0.001). CONCLUSIONS Among normal weight individuals without manifest cardiovascular disease, the combination of central fat distribution and low lean mass is associated with higher cfPWV. These factors are more closely related to cfPWV than total fat mass.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

AMERICAN JOURNAL OF HYPERTENSION

ISSN

0895-7061

e-ISSN

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Volume of the periodical

28

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

401-408

UT code for WoS article

000352203600015

EID of the result in the Scopus database

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