Polymorphisms in microRNA genes as predictors of clinical outcomes in colorectal cancer patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F15%3A%230001080" target="_blank" >RIV/00064190:_____/15:#0001080 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/15:00451835 RIV/00216208:11110/15:10294654

Result on the web

<a href="http://clincancerres.aacrjournals.org/content/18/14/3982.long" target="_blank" >http://clincancerres.aacrjournals.org/content/18/14/3982.long</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/carcin/bgu224" target="_blank" >10.1093/carcin/bgu224</a>

Result language

angličtina

Original language name

Polymorphisms in microRNA genes as predictors of clinical outcomes in colorectal cancer patients

Original language description

This study investigates whether variants in miRNA genes, previously associated with prognosis, can predict CRC clinical outcome in CRC patients from the Czech Republic. Two polymorphisms in miRNAs resulted significantly associated with survival/recurrence in patients undergoing 5-FU-based chemotherapy.Colorectal cancer (CRC) is one of the most frequently diagnosed malignancies worldwide. It is routinely cured by a 5-fluorouracil (5-FU)-based chemotherapy which improves outcomes in patients. We investigated the effect of single nucleotide polymorphisms (SNPs) in two microRNA (miRNA)-encoding genes that have been previously reported as important in prognosis in patients with stage III CRC and treated with 5-FU-based chemotherapy. Two SNPs (rs4919510 in miR-608 and rs213210 in miR-219-1) were genotyped in 1083 CRC patients recruited in the Czech Republic to evaluate their effect on clinical outcomes. Carriers of the variant T allele in rs213210 and receiving 5-FU chemotherapy were associa

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

CARCINOGENESIS

ISSN

0143-3334

e-ISSN

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Volume of the periodical

36

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

82-86

UT code for WoS article

000347844700011

EID of the result in the Scopus database

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