Variations in mismatch repair genes and colorectal cancer risk and clinical outcome

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F14%3A10282944" target="_blank" >RIV/00064165:_____/14:10282944 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/14:00430217 RIV/00064190:_____/14:#0000804 RIV/00216208:11110/14:10282944

Result on the web

<a href="http://dx.doi.org/10.1093/mutage/geu014" target="_blank" >http://dx.doi.org/10.1093/mutage/geu014</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/mutage/geu014" target="_blank" >10.1093/mutage/geu014</a>

Result language

angličtina

Original language name

Variations in mismatch repair genes and colorectal cancer risk and clinical outcome

Original language description

DNA mismatch repair (MMR) deficiency is one of the best understood forms of genetic instability in colorectal cancer (CRC). CRC is routinely cured by 5-fluorouracil (5-FU)-based chemotherapy, with a prognostic effect and resistance to such therapy conferred by MMR status. In this study, we aimed to analyse the effect of genetic variants in classical coding regions or in less-explored predicted microRNA (miRNA)-binding sites in the 3' untranslated region (3'UTR) of MMR genes on the risk of CRC, prognosisand the efficacy of 5-FU therapy. Four single nucleotide polymorphisms (SNPs) in MMR genes were initially tested for susceptibility to CRC in a case-control study (1095 cases and 1469 healthy controls). Subsequently, the same SNPs were analysed for their role in survival on a subset of patients with complete follow-up. Two SNPs in MLH3 and MSH6 were associated with clinical outcome. Among cases with colon and sigmoideum cancer, carriers of the CC genotype of rs108621 in the 3'UTR of MLH

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mutagenesis

ISSN

0267-8357

e-ISSN

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Volume of the periodical

29

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

259-265

UT code for WoS article

000337925200005

EID of the result in the Scopus database

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