Influence of age on manifestation, VC and TLCO values, and bronchoalveolar lavage cell counts of sarcoidosis and extrinsic allergic alveolitis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F15%3A%230001082" target="_blank" >RIV/00064190:_____/15:#0001082 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/15:00059220
Result on the web
<a href="http://dx.doi.org/10.1111/crj.12102" target="_blank" >http://dx.doi.org/10.1111/crj.12102</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/crj.12102" target="_blank" >10.1111/crj.12102</a>
Alternative languages
Result language
angličtina
Original language name
Influence of age on manifestation, VC and TLCO values, and bronchoalveolar lavage cell counts of sarcoidosis and extrinsic allergic alveolitis
Original language description
IntroductionImmune response probably changes during human life, being influenced by cumulative exposure to environmental factors and individual genetic background. MethodsPatients investigated for suspected interstitial lung disease were prospectively enrolled. After completing the diagnostic process, 121 patients were diagnosed extrinsic allergic alveolitis (EAA) and 136 sarcoidosis. Three groups according to age were established (<30 years, 30-60 years, >60 years), clinical manifestation, vital capacity (VC), forced expired volume in 1s (FEV1), lung diffusing capacity for carbon monoxide-transfer factor (TLCO) and bronchoalveolar lavage fluid (BALF) differential cell count were compared among the groups. ResultsAge subgroups of EAA patients did not significantly differ in lung functions. In the group above 60 years, non-significantly higher neutrophils and eosinophils counts and CD4/CD8 ratio were observed. Sarcoidosis patients were significantly younger than EAA group and had significantly better lung functions (VC, FEV1, TLCO). Patients with sarcoidosis above 60 years of age had significantly higher percentages of neutrophils in BALF compared with younger patients. BALF percentage of neutrophils positively correlated with age. ConclusionsPresented results may support the hypothesis that reactivity of immune system changes during the life, which may result in different manifestation of interstitial lung diseases according to age.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FC - Pneumology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT13433" target="_blank" >NT13433: Immuno-pathogenetic backing data for the fibro-genesis for interstitial pulmonary processes, biomarkers of fibro-genesis</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CLINICAL RESPIRATORY JOURNAL
ISSN
1752-6981
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
39-44
UT code for WoS article
000347381800007
EID of the result in the Scopus database
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