Role of interleukin 4 and its receptor in clinical presentation of chronic extrinsic allergic alveolitis: a pilot study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F13%3A10193214" target="_blank" >RIV/00064203:_____/13:10193214 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/13:00058670 RIV/00064190:_____/13:#0000596 RIV/00216208:11130/13:10193214

Result on the web

<a href="http://www.mrmjournal.com/content/8/1/35" target="_blank" >http://www.mrmjournal.com/content/8/1/35</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/2049-6958-8-35" target="_blank" >10.1186/2049-6958-8-35</a>

Result language

angličtina

Original language name

Role of interleukin 4 and its receptor in clinical presentation of chronic extrinsic allergic alveolitis: a pilot study

Original language description

Background: Th-2 cytokine milieu including interleukin 4 (IL-4) was detected in fibrotic lung diseases. Chronic extrinsic allergic alveolitis (EAA) may be also accompanied by marked fibrogenesis. The aim of this study was to determine if IL-4 and its receptor (IL-4R-alpha) play any role in the clinical presentation and pathogenesis of chronic EAA. Methods: Twenty patients originally investigated for interstitial lung disease and finally diagnosed affected with chronic EAA and sarcoidosis were prospectively enrolled into the study. Concentrations of IL-4, IL-4R-aplha and total protein were assessed in the bronchoalveolar lavage fluid (BALF) of all enrolled subjects as well as high resolution computed tomography (HRCT) scores and pulmonary function tests. Results: BALF IL-4R-alpha and total protein concentrations were significantly higher in chronic EAA patients (p < 0.05). Concentrations of BALF IL-4R-alpha were significantly higher in men than in women (p < 0.05) in EAA group. Total pr

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FC - Pneumology

OECD FORD branch

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Project

<a href="/en/project/NT13433" target="_blank" >NT13433: Immuno-pathogenetic backing data for the fibro-genesis for interstitial pulmonary processes, biomarkers of fibro-genesis</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Multidisciplinary Respiratory Medicine

ISSN

2049-6958

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

35

Country of publishing house

IT - ITALY

Number of pages

1

Pages from-to

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UT code for WoS article

000323110800001

EID of the result in the Scopus database

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