PAR-2, IL-4R, TGF-beta and TNF-alpha in bronchoalveolar lavage distinguishes extrinsic allergic alveolitis from sarcoidosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F14%3A00223770" target="_blank" >RIV/68407700:21340/14:00223770 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/14:00432081 RIV/00216208:11120/14:43908579 RIV/00064190:_____/14:#0000798
Result on the web
<a href="http://dx.doi.org/10.3892/etm.2014.1776" target="_blank" >http://dx.doi.org/10.3892/etm.2014.1776</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3892/etm.2014.1776" target="_blank" >10.3892/etm.2014.1776</a>
Alternative languages
Result language
angličtina
Original language name
PAR-2, IL-4R, TGF-beta and TNF-alpha in bronchoalveolar lavage distinguishes extrinsic allergic alveolitis from sarcoidosis
Original language description
Sarcoidosis (SARC) and extrinsic allergic alveolitis (EAA) share certain markers, making a differential diagnosis difficult even with histopathological investigation. In lung tissue, proteinase-activated receptor-2 (PAR-2) is primarily investigated withregard to epithelial and inflammatory perspectives. Varying levels of certain chemokines can be a useful tool for distinguishing EAA and SARC. Thus, in the present study, differences in the levels of transforming growth factor (TGF)-beta 1, tumor necrosis factor (TNF)-alpha, interleukin-4 receptor (IL-4R) and PAR-2 in bronchoalveolar lavage fluid (BALF) were compared, using an ELISA method, between 14 patients with EAA and six patients with SARC. Statistically significant higher levels of IL-4R, PAR-2 and the PAR-2/TGF-beta 1 and PAR-2/TNF-alpha ratios were observed in EAA patients as compared with SARC patients. Furthermore, the ratios of TNF-alpha/total protein, TGF-beta 1/PAR-2 and TNF-alpha/PAR-2 were significantly lower in EAA pati
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT13433" target="_blank" >NT13433: Immuno-pathogenetic backing data for the fibro-genesis for interstitial pulmonary processes, biomarkers of fibro-genesis</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
EXPERIMENTAL AND THERAPEUTIC MEDICINE
ISSN
1792-0981
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
2
Country of publishing house
GR - GREECE
Number of pages
6
Pages from-to
533-538
UT code for WoS article
000339127500034
EID of the result in the Scopus database
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