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Biomarkers of fibroproliferative healing in fibrosing idiopathic interstitial pneumonias.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F12%3A%230000388" target="_blank" >RIV/00064190:_____/12:#0000388 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.2174/1874306401206010160" target="_blank" >http://dx.doi.org/10.2174/1874306401206010160</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2174/1874306401206010160" target="_blank" >10.2174/1874306401206010160</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Biomarkers of fibroproliferative healing in fibrosing idiopathic interstitial pneumonias.

  • Original language description

    AIMS: The main feature of fibrosing idiopathic interstitial pneumonias (fIIPs) is the fibroproliferative potential of underlying pathogenetic process. We hypothesize that the concentration of potential markers of fibroproliferative healing, PAR-2, TGF-?1, TNF-? and IL-4R? in bronchoalveolar lavage fluid (BALF) differ in patients with fIIPs compared to controls (C). PATIENTS AND METHODS: 10 patients with fIIPs and 9 controls (C) were included to the study. Concentrations of CD124 (IL4R?), PAR-2, TGF-?1 and TNF-? in BALF were determined using the ELISA method. RESULTS: We observed higher concentrations of IL4R? (fIIPS 1499.4 pg/ml vs C 255.5 pg/ml; p < 0.05), PAR-2 (fIIPS 1807.9 pg/ml vs C 421.0 pg/ml; p < 0.05) and TGF-?1(fIIPS 283.0 pg/ml vs C 197.1 pg/ml; p < 0.01) in BALF in fIIPs versus C. The values of TNF-a in BALF did not differ significantly in fIIPs compared to controls. The ratios also showed differences in fIIPS and C: IL4R?/TGF-?1 (fIIPS 6.19 vs C 0.68; p = 0.0143); TNF-?/IL

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FC - Pneumology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NS10423" target="_blank" >NS10423: PAR´s, chemokines and their receptors´ expression changes in pulmonary fibrosing processes and in pulmonary processes with alveolar number reduction without scaring (IPF vs. COPD)</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    The open respiratory medicine journal

  • ISSN

    1874-3064

  • e-ISSN

  • Volume of the periodical

    2012

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    5

  • Pages from-to

    160-164

  • UT code for WoS article

  • EID of the result in the Scopus database