Biomarkers of fibroproliferative healing in fibrosing idiopathic interstitial pneumonias.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F12%3A%230000388" target="_blank" >RIV/00064190:_____/12:#0000388 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2174/1874306401206010160" target="_blank" >http://dx.doi.org/10.2174/1874306401206010160</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1874306401206010160" target="_blank" >10.2174/1874306401206010160</a>
Alternative languages
Result language
angličtina
Original language name
Biomarkers of fibroproliferative healing in fibrosing idiopathic interstitial pneumonias.
Original language description
AIMS: The main feature of fibrosing idiopathic interstitial pneumonias (fIIPs) is the fibroproliferative potential of underlying pathogenetic process. We hypothesize that the concentration of potential markers of fibroproliferative healing, PAR-2, TGF-?1, TNF-? and IL-4R? in bronchoalveolar lavage fluid (BALF) differ in patients with fIIPs compared to controls (C). PATIENTS AND METHODS: 10 patients with fIIPs and 9 controls (C) were included to the study. Concentrations of CD124 (IL4R?), PAR-2, TGF-?1 and TNF-? in BALF were determined using the ELISA method. RESULTS: We observed higher concentrations of IL4R? (fIIPS 1499.4 pg/ml vs C 255.5 pg/ml; p < 0.05), PAR-2 (fIIPS 1807.9 pg/ml vs C 421.0 pg/ml; p < 0.05) and TGF-?1(fIIPS 283.0 pg/ml vs C 197.1 pg/ml; p < 0.01) in BALF in fIIPs versus C. The values of TNF-a in BALF did not differ significantly in fIIPs compared to controls. The ratios also showed differences in fIIPS and C: IL4R?/TGF-?1 (fIIPS 6.19 vs C 0.68; p = 0.0143); TNF-?/IL
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FC - Pneumology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NS10423" target="_blank" >NS10423: PAR´s, chemokines and their receptors´ expression changes in pulmonary fibrosing processes and in pulmonary processes with alveolar number reduction without scaring (IPF vs. COPD)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The open respiratory medicine journal
ISSN
1874-3064
e-ISSN
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Volume of the periodical
2012
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
160-164
UT code for WoS article
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EID of the result in the Scopus database
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