Bronchoalveolar lavage cell profiles and proteins concentrations can be used to phenotype extrinsic allergic alveolitis patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00077800" target="_blank" >RIV/00023001:_____/19:00077800 - isvavai.cz</a>
Alternative codes found
RIV/00064190:_____/19:N0000072
Result on the web
<a href="https://mrmjournal.biomedcentral.com/track/pdf/10.1186/s40248-019-0175-6" target="_blank" >https://mrmjournal.biomedcentral.com/track/pdf/10.1186/s40248-019-0175-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s40248-019-0175-6" target="_blank" >10.1186/s40248-019-0175-6</a>
Alternative languages
Result language
angličtina
Original language name
Bronchoalveolar lavage cell profiles and proteins concentrations can be used to phenotype extrinsic allergic alveolitis patients
Original language description
Background Extrinsic allergic alveolitis (EAA) patients form heterogenous group with different clinical manifestation and different prognosis. We aimed to determine how to phenotype distinct EAA subgroups. Predictive role of the bronchoalveolar lavage fluid (BALF) IL-4R concentration at the time of diagnosis with regard to the clinical behavior in EAA patients was studied. Methods Concentrations of MMP-7, IL-4R, TNF-, and PAR-2 were measured in the BALF od 71 EAA patients at the time of diagnosis. Lung functions and outcome data were assessed at 12months after the diagnosis. Correlations between the BALF protein concentration, cell profile, lung functions and patient outcome were determined.Results We found positive correlations between BALF IL-4R concentration and BALF eosinophils (p=0,006), negative correlation between IL-4R BALF concentration and diffusing capacity (DLco) (p=0,003), negative correlation between IL-4R BALF concentration and forced vital capacity (FVC) (p=0,004) and negative correlation between IL-4R concentration and BALF lymphocytes (p=0,04). The BALF concentration of IL-4R was significantly higher in acute exacerbation patients (p=0,0032) and in patients progressing despite corticosteroid treatment (p=0,04). We observed a positive correlation between MMP-7 BALF concentration and the BALF lymphocytes (p=0.05), negative correlation between the PAR-2 BALF concentration and DLco (p=0.04) and a negative correlation between the BALF TNF- concentration and DLco (p=0.03). Conclusions Specific subgroup of EAA patients with more severe functional impact, distinct BALF cell profile and higher IL-4R BALF concentration can be differentiated. Correlations between the BALF concentrations of PAR-2, MMP-7 and TNF- with clinical parameters may reflect the role of inflammation in the pathogenesis of EAA.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30203 - Respiratory systems
Result continuities
Project
—
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Multidisciplinary respiratory medicine
ISSN
2049-6958
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
March 12
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
"art. no. 13"
UT code for WoS article
000461046400001
EID of the result in the Scopus database
2-s2.0-85062889199