Immunotherapy of Sepsis: Blind Alley or Call for Personalized Assessmen?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F16%3AN0000216" target="_blank" >RIV/00064190:_____/16:N0000216 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00005-016-0415-9" target="_blank" >http://dx.doi.org/10.1007/s00005-016-0415-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00005-016-0415-9" target="_blank" >10.1007/s00005-016-0415-9</a>

Result language

angličtina

Original language name

Immunotherapy of Sepsis: Blind Alley or Call for Personalized Assessmen?

Original language description

Sepsis is the most frequent cause of death in noncoronary intensive care units. In the past 10 years, progress has been made in the early identification of septic patients and their treatment. These improvements in support and therapy mean that mortality is gradually decreasing, however, the rate of death from sepsis remains unacceptably high. Immunotherapy is not currently part of the routine treatment of sepsis. Despite experimental successes, the administration of agents to block the effect of sepsis mediators failed to show evidence for improved outcome in a multitude of clinical trials. The following survey summarizes the current knowledge and results of clinical trials on the immunotherapy of sepsis and describes the limitations of our knowledge of the pathogenesis of sepsis. Administration of immunomodulatory drugs should be linked to the current immune status assessed by both clinical and molecular patterns. Thus, a careful daily review of the patient's immune status needs to be introduced into routine clinical practice giving the opportunity for effective and tailored use of immunomodulatory therapy.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

ISSN

0004-069X

e-ISSN

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Volume of the periodical

65

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

37-49

UT code for WoS article

000397235200004

EID of the result in the Scopus database

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