Immunotherapy of Sepsis: Blind Alley or Call for Personalized Assessment?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10362033" target="_blank" >RIV/00216208:11110/17:10362033 - isvavai.cz</a>
Alternative codes found
RIV/00023884:_____/12:00007422 RIV/00064190:_____/17:N0000070
Result on the web
<a href="http://dx.doi.org/10.1007/s00005-016-0415-9" target="_blank" >http://dx.doi.org/10.1007/s00005-016-0415-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00005-016-0415-9" target="_blank" >10.1007/s00005-016-0415-9</a>
Alternative languages
Result language
angličtina
Original language name
Immunotherapy of Sepsis: Blind Alley or Call for Personalized Assessment?
Original language description
Sepsis is the most frequent cause of death in noncoronary intensive care units. In the past 10 years, progress has been made in the early identification of septic patients and their treatment. These improvements in support and therapy mean that mortality is gradually decreasing, however, the rate of death from sepsis remains unacceptably high. Immunotherapy is not currently part of the routine treatment of sepsis. Despite experimental successes, the administration of agents to block the effect of sepsis mediators failed to show evidence for improved outcome in a multitude of clinical trials. The following survey summarizes the current knowledge and results of clinical trials on the immunotherapy of sepsis and describes the limitations of our knowledge of the pathogenesis of sepsis. Administration of immunomodulatory drugs should be linked to the current immune status assessed by both clinical and molecular patterns. Thus, a careful daily review of the patient's immune status needs to be introduced into routine clinical practice giving the opportunity for effective and tailored use of immunomodulatory therapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Archivum Immunologiae et Therapiae Experimentalis
ISSN
0004-069X
e-ISSN
—
Volume of the periodical
65
Issue of the periodical within the volume
1
Country of publishing house
CH - SWITZERLAND
Number of pages
13
Pages from-to
37-49
UT code for WoS article
000397235200004
EID of the result in the Scopus database
2-s2.0-84983410462