Role of chemokines in resectable non-small cell lung cancer (NSCLC)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F19%3AN0000122" target="_blank" >RIV/00064190:_____/19:N0000122 - isvavai.cz</a>
Result on the web
<a href="https://www.annalsofoncology.org/article/S0923-7534(19)30224-8/fulltext" target="_blank" >https://www.annalsofoncology.org/article/S0923-7534(19)30224-8/fulltext</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/annonc/mdz072.007" target="_blank" >10.1093/annonc/mdz072.007</a>
Alternative languages
Result language
angličtina
Original language name
Role of chemokines in resectable non-small cell lung cancer (NSCLC)
Original language description
Background: Complex network of chemokines is a part of immune reaction targeted against tumor cells. Chemokines influence cancer growth. It is not clear whether the concentrations of chemokines at the time of diagnosis of NSCLC reflect extent of the disease. Aim: To compare chemokine concentrations (CCL2, CCL8, CXCL12) in plasma of patients with resectable NSCLC to those without cancer. To find out whether the chemokine concentrations differ according to stage of the disease. Methods: We enrolled 69 patients undergoing surgery for proven/suspected NSCLC (37 males- mean age 66 years, 32 females- mean age 64 years). They underwent standard diagnostic and staging procedure to determine resectability (CT/PET-CT, bronchoscopy, ev. abdominal ultrasound), then surgery was made. We diagnosed 42 patients with NSCLC, 27 patients in the control group had benign lung pathologies (e.g. chondrohamatoma, fibrous tissue) and remained as the control group. We took plasma samples before surgery in treatment naive patients. The chemokine concentrations were assesed by ELISA LSBio Kits. The results were stated in pg/ml (CCL2, CCL8), ng/ml (CXCL12). Parametric statistics was used for results analysis. Conclusions: Chemokine values did not differ in NSCLC versus control group. Patients with NSCLC stages II and IIIA had significantly higher CXCL12 concentrations than control group. This could be because CXCL12 promotes tumor growth and metastasis.
Czech name
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Czech description
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Classification
Type
J<sub>ost</sub> - Miscellaneous article in a specialist periodical
CEP classification
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OECD FORD branch
30203 - Respiratory systems
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Annals of oncology : official journal of the European Society for Medical Oncology
ISSN
0923-7534
e-ISSN
1569-8041
Volume of the periodical
neuveden
Issue of the periodical within the volume
04/2019
Country of publishing house
GB - UNITED KINGDOM
Number of pages
1
Pages from-to
Suppl 2:ii3
UT code for WoS article
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EID of the result in the Scopus database
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