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CCL2, CCL8, CXCL12 chemokines in resectable non-small cell lung cancer (NSCLC)

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F23%3A10001185" target="_blank" >RIV/00064190:_____/23:10001185 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/23:10453593 RIV/00216208:11120/23:43925032

  • Result on the web

    <a href="https://biomed.papers.upol.cz/artkey/bio-202304-0004_ccl2-ccl8-cxcl12-chemokines-in-resectable-non-small-cell-lung-cancer-nsclc.php" target="_blank" >https://biomed.papers.upol.cz/artkey/bio-202304-0004_ccl2-ccl8-cxcl12-chemokines-in-resectable-non-small-cell-lung-cancer-nsclc.php</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.5507/BP.2022.050" target="_blank" >10.5507/BP.2022.050</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    CCL2, CCL8, CXCL12 chemokines in resectable non-small cell lung cancer (NSCLC)

  • Original language description

    Background. Complex networks of chemokines are part of the immune reaction targeted against tumor cells. Chemokines influence cancer growth. It is unclear whether the concentrations of chemokines at the time of NSCLC (non-small cell lung cancer) diagnosis differ from healthy controls and reflect the extent of NSCLC. Aims. To compare chemokine concentrations (CCL2, CCL8, CXCL12) in the plasma of patients with resectable NSCLC to those without cancer. To determine whether the chemokine concentrations differ relative to the stage of disease. Methods. Sixty-nine patients undergoing surgery for proven/suspected NSCLC were enrolled. They underwent standard diagnostic and staging procedures to determine resectability, surgery was performed. Forty-two patients were diagnosed with NSCLC, while 27patients had benign lung lesions and functioned as the control group. Chemokine concentrations in peripheral blood were assessed using ELISA. Parametric statistics were used for the analysis of results. Results. There were no differences in plasma chemokine concentrations in NSCLC patients compared to controls. CXCL12 concentrations correlated positively with tumor extent expressed as clinical stage, (mean values: stage I 5.08 ng/mL, SEM 0.59; stage II and IIIA 7.82 ng/mL; SEM 1.06; P=0.022). Patients with NSCLC stages II+IIIA had significantly higher CXCL12 concentrations than controls (mean values: stage II+IIIA 7.82 ng/mL; SEM 1.06; controls 5.3 ng/mL; SEM 0.46; P=0.017). Conclusion. CXCL12 was related to tumor growth and could potentially be used as a biomarker of advanced disease. (C) 2023 The Authors.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30203 - Respiratory systems

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    BIOMEDICAL PAPERS-OLOMOUC

  • ISSN

    1213-8118

  • e-ISSN

  • Volume of the periodical

    167

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    5

  • Pages from-to

    335-339

  • UT code for WoS article

    000917083600001

  • EID of the result in the Scopus database

    2-s2.0-85179772822