A multi-country study of prevalence and early childhood mortality among children with omphalocele
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F20%3AN0000032" target="_blank" >RIV/00064190:_____/20:N0000032 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/bdr2.1822" target="_blank" >http://dx.doi.org/10.1002/bdr2.1822</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/bdr2.1822" target="_blank" >10.1002/bdr2.1822</a>
Alternative languages
Result language
angličtina
Original language name
A multi-country study of prevalence and early childhood mortality among children with omphalocele
Original language description
Background Omphalocele is the second most common abdominal birth defect and often occurs with other structural and genetic defects. The objective of this study was to determine omphalocele prevalence, time trends, and mortality during early childhood, by geographical region, and the presence of associated anomalies. Methods We conducted a retrospective study with 23 birth defect surveillance systems in 18 countries who are members of the International Clearinghouse for Birth Defects Surveillance and Research that submitted data on cases ascertained from 2000 through 2012, approximately 16 million pregnancies were surveyed that resulted in live births, stillbirths, or elective terminations of pregnancy for fetal anomalies (ETOPFA) and cases with omphalocele were included. Overall prevalence and mortality rates for specific ages were calculated (day of birth, neonatal, infant, and early childhood). We used Kaplan-Meier estimates with 95% confidence intervals (CI) to calculate cumulative mortality and joinpoint regression for time trend analyses. Results The prevalence of omphalocele was 2.6 per 10,000 births (95% CI: 2.5, 2.7) and showed no temporal change from 2000-2012 (average annual percent change = -0.19%,p= .52). The overall mortality rate was 32.1% (95% CI: 30.2, 34.0). Most deaths occurred during the neonatal period and among children with multiple anomalies or syndromic omphalocele. Prevalence and mortality varied by registry type (e.g., hospital- vs. population-based) and inclusion or exclusion of ETOPFA. Conclusions The prevalence of omphalocele showed no temporal change from 2000-2012. Approximately one-third of children with omphalocele did not survive early childhood with most deaths occurring in the neonatal period.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
<a href="/en/project/NV17-29622A" target="_blank" >NV17-29622A: Effectiveness analysis of prenatal diagnosis of congenital malformations and survival of children born with a birth defect in 1994 – 2015</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BIRTH DEFECTS RESEARCH
ISSN
2472-1727
e-ISSN
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Volume of the periodical
112
Issue of the periodical within the volume
20
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
1787-1801
UT code for WoS article
000577931400001
EID of the result in the Scopus database
2-s2.0-85092565490