Serotonin-Its Synthesis and Roles in the Healthy and the Critically Ill

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F21%3AN0000062" target="_blank" >RIV/00064190:_____/21:N0000062 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/21:43921481 RIV/00843989:_____/21:E0109005
Result on the web
<a href="http://dx.doi.org/10.3390/ijms22094837" target="_blank" >http://dx.doi.org/10.3390/ijms22094837</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms22094837" target="_blank" >10.3390/ijms22094837</a>

Result language
angličtina
Original language name
Serotonin-Its Synthesis and Roles in the Healthy and the Critically Ill
Original language description
erotonin (5-hydroxytryptamine, 5-HT) plays two important roles in humans-one central and the other peripheral-depending on the location of the 5-HT pools of on either side of the blood-brain barrier. In the central nervous system it acts as a neurotransmitter, controlling such brain functions as autonomic neural activity, stress response, body temperature, sleep, mood and appetite. This role is very important in intensive care, as in critically ill patients multiple serotoninergic agents like opioids, antiemetics and antidepressants are frequently used. High serotonin levels lead to altered mental status, deliria, rigidity and myoclonus, together recognized as serotonin syndrome. In its role as a peripheral hormone, serotonin is unique in controlling the functions of several organs. In the gastrointestinal tract it is important for regulating motor and secretory functions. Apart from intestinal motility, energy metabolism is regulated by both central and peripheral serotonin signaling. It also has fundamental effects on hemostasis, vascular tone, heart rate, respiratory drive, cell growth and immunity. Serotonin regulates almost all immune cells in response to inflammation, following the activation of platelets.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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