Serotonin attenuates tumor necrosis factor-induced intestinal inflammation by interacting with human mucosal tissue

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00082328" target="_blank" >RIV/00159816:_____/25:00082328 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/25:00140726 RIV/00023736:_____/25:00013780

Result on the web

<a href="https://www.nature.com/articles/s12276-025-01397-1" target="_blank" >https://www.nature.com/articles/s12276-025-01397-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s12276-025-01397-1" target="_blank" >10.1038/s12276-025-01397-1</a>

Result language

angličtina

Original language name

Serotonin attenuates tumor necrosis factor-induced intestinal inflammation by interacting with human mucosal tissue

Original language description

The intestine hosts the largest immune system and peripheral nervous system in the human body. The gut-brain axis orchestrates communication between the central and enteric nervous systems, playing a pivotal role in regulating overall body function and intestinal homeostasis. Here, using a human three-dimensional in vitro culture model, we investigated the effects of serotonin, a neuromodulator produced in the gut, on immune cell and intestinal tissue interactions. Serotonin attenuated the tumor necrosis factor-induced proinflammatory response, mostly by affecting the expression of chemokines. Serotonin affected the phenotype and distribution of tissue-migrating monocytes, without direct contact with the cells, by remodeling the intestinal tissue. Collectively, our results show that serotonin plays a crucial role in communication among gut-brain axis components and regulates monocyte migration and plasticity, thereby contributing to gut homeostasis and the progression of inflammation. In vivo studies focused on the role of neuromodulators in gut inflammation have shown controversial results, highlighting the importance of human experimental models. Moreover, our results emphasize the importance of human health research in human cell-based models and suggest that the serotonin signaling pathway is a new therapeutic target for inflammatory bowel disease.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30102 - Immunology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

EXPERIMENTAL AND MOLECULAR MEDICINE

ISSN

1226-3613

e-ISSN

2092-6413

Volume of the periodical

57

Issue of the periodical within the volume

2

Country of publishing house

KR - KOREA, REPUBLIC OF

Number of pages

15

Pages from-to

364-378

UT code for WoS article

001410786000001

EID of the result in the Scopus database

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