Determining priority risk groups for compensation of treatment breaks in radical radiotherapy in patients with locally advanced head and neck cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F21%3AN0000065" target="_blank" >RIV/00064190:_____/21:N0000065 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10429241 RIV/00064203:_____/21:10429241 RIV/00216208:11130/21:10429241
Result on the web
<a href="https://www.jbuon.com/archive/26-3-792.pdf" target="_blank" >https://www.jbuon.com/archive/26-3-792.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Determining priority risk groups for compensation of treatment breaks in radical radiotherapy in patients with locally advanced head and neck cancer
Original language description
Purpose: Prolongation of radiotherapy worsens the results of treatment of head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to identify the prognostic factors most affected by the prolongation of treatment. Methods: 184 patients with locally advanced HNSCC were treated with curative chemoradiation using SIB-IMRT from 2008 to 2016 and the influence of radiotherapy time (RTT) in groups of patients according to prognostic factors was retrospectively evaluated. Results: Median overall survival (OS) was 45 months, median disease-free survival (DFS) was 41 months and median local control (LC) was not reached (mean LRC 68 months). In the multivariate analysis the radiotherapy prolongation negatively affected the LC in stage IV patients, T3/T4, in neck nodes positive disease, in oropharyngeal and oral cavity cancers, after neoadjuvant chemotherapy and in men. The RTT effect on DFS was significant in stage IV patients, patients with neck nodes positive disease and oropharyngeal cancer. RTT prolongation decreased OS within the groups of stage IV and grade 3 tumours. Conclusion: Prolonged RTT was associated with worsened OS and LRC, especially in stage IV patients and/or neck node positive disease and/or oropharyngeal cancer and we recommend that these patients should be prioritized in treat- ment gap compensation in radical radiotherapy for locally advanced HNSCC.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF BUON
ISSN
1107-0625
e-ISSN
2241-6293
Volume of the periodical
26
Issue of the periodical within the volume
3
Country of publishing house
GR - GREECE
Number of pages
10
Pages from-to
792-801
UT code for WoS article
000668815400023
EID of the result in the Scopus database
2-s2.0-85109631699