Serum and Mucosal CD30 in Pediatric Inflammatory Bowel Diseases: Useful Biomarker for Diagnosis and Disease Activity Monitoring?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F22%3AN0000026" target="_blank" >RIV/00064190:_____/22:N0000026 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/23:10446519 RIV/00216208:11120/23:43923821 RIV/00064203:_____/23:10446519 RIV/00064190:_____/23:10000965 RIV/00023001:_____/23:00083799

Result on the web

<a href="https://doi.org/10.1007/s10620-022-07677-4" target="_blank" >https://doi.org/10.1007/s10620-022-07677-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10620-022-07677-4" target="_blank" >10.1007/s10620-022-07677-4</a>

Result language

angličtina

Original language name

Serum and Mucosal CD30 in Pediatric Inflammatory Bowel Diseases: Useful Biomarker for Diagnosis and Disease Activity Monitoring?

Original language description

Background Inflammatory bowel diseases (IBD) frequently manifest in pediatric age, but may have atypical clinical, histological and laboratory features. Their underlying immune pathophysiology is incompletely understood, rendering quick diagnosis followed by tailored therapy difficult. The tumor necrosis factor superfamily receptor CD30 has been proposed as a potential marker of ulcerative colitis (UC) and has also been associated with elevated Th2 helper T cells. Methods A cohort of pediatric patients with UC and Crohn's disease (CD) was evaluated for serum soluble CD30 (sCD30) using ELISA and expression of CD30 and subpopulations of Th1/Th2/Th17 lymphocytes in the gastrointestinal mucosa using flow cytometry (FCM). The dataset is supported by endoscopic and microscopic activity of the disease and basic laboratory markers of inflammation. Results The cohort consisted of 102 observations from 94 patients. sCD30 levels did not differ between patients with CD or UC. However, sCD30 levels correlated with levels of CRP, ESR, fecal calprotectin and albumin and also with clinical activity of the disease in patients with both UC and CD. FCM was not helpful in evaluation of mucosal CD30, which was lowly expressed and not associated with the diagnosis or disease activity. We show augmented Th2 and Th1/17 response in terminal ileum and right-sided colon and decreased Th1/17 response in left-sided colon of UC patients. T lymphocyte subsets were also affected by anti-TNF treatment and patients' age. Conclusions Neither sCD30 nor mucosal CD30 expression was helpful in differentiating between UC and CD. sCD30 seems to reflect a degree of systemic inflammation and clinical activity in IBD

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30219 - Gastroenterology and hepatology

Project

<a href="/en/project/NU20-05-00282" target="_blank" >NU20-05-00282: T-MAPs: High content mapping of surface molecules in normal and disturbed development T lymphocytes, a search for diagnostic and therapeutic targets</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

DIGESTIVE DISEASES AND SCIENCES

ISSN

0163-2116

e-ISSN

1573-2568

Volume of the periodical

68

Issue of the periodical within the volume

2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

11

Pages from-to

460-470

UT code for WoS article

000849441700001

EID of the result in the Scopus database

2-s2.0-85137487582