DNA methylation-associated colonic mucosal immune and defense responses in treatment-naive pediatric ulcerative colitis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10292957" target="_blank" >RIV/00064203:_____/14:10292957 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/14:10292957

Result on the web

<a href="http://dx.doi.org/10.4161/epi.29446" target="_blank" >http://dx.doi.org/10.4161/epi.29446</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4161/epi.29446" target="_blank" >10.4161/epi.29446</a>

Result language

angličtina

Original language name

DNA methylation-associated colonic mucosal immune and defense responses in treatment-naive pediatric ulcerative colitis

Original language description

Inflammatory bowel diseases (IBD) are emerging globally, indicating that environmental factors may be important in their pathogenesis. Colonic mucosal epigenetic changes, such as DNA methylation, can occur in response to the environment and have been implicated in IBD pathology. However, mucosal DNA methylation has not been examined in treatment-naive patients. We studied DNA methylation in untreated, left sided colonic biopsy specimens using the Infinium HumanMethylation450 BeadChip array. We analyzed22 control (C) patients, 15 untreated Crohn's disease (CD) patients, and 9 untreated ulcerative colitis (UC) patients from two cohorts. Samples obtained at the time of clinical remission from two of the treatment-naive UC patients were also included intothe analysis. UC-specific gene expression was interrogated in a subset of adjacent samples (5 C and 5 UC) using the Affymetrix GeneChip PrimeView Human Gene Expression Arrays. Only treatment-naive UC separated from control. One-hundred-a

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Epigenetics

ISSN

1559-2294

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

8

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

1131-1137

UT code for WoS article

000341360600008

EID of the result in the Scopus database

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