Proteinase-activated Receptor 2: Springboard of Tumors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F24%3A10001072" target="_blank" >RIV/00064190:_____/24:10001072 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/24:43924624 RIV/00216208:11110/24:10473853 RIV/00216208:11120/24:43926545
Result on the web
<a href="https://ar.iiarjournals.org/content/anticanres/44/1/1.full.pdf" target="_blank" >https://ar.iiarjournals.org/content/anticanres/44/1/1.full.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21873/anticanres.16782" target="_blank" >10.21873/anticanres.16782</a>
Alternative languages
Result language
angličtina
Original language name
Proteinase-activated Receptor 2: Springboard of Tumors
Original language description
Proteinase-activated receptors (PARs) were discovered more than 25 years ago and since then, their role in cancer has been under investigation. Research has primarily focused on the receptors located on the membrane of cancer cells and their impact on metabolism, intracellular signalling, and proliferation. Regarding the host response to cancer, studies have predominantly examined the relationship of thrombin receptors (PAR-1, PAR-3, and PAR -4) with blood clotting in distant metastatic spread. However, limited studies have examined the role of PARs, especially PAR-2, in the host anti-tumor immunity. This review article provides insights into the role of PAR-2 on cancer cells and immune competent cells involved in cancer development and progression. It also discussed the current knowledge of the importance of PAR-2 activation at various stages of cancer progression and its association with cancer-related pain.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ANTICANCER RESEARCH
ISSN
0250-7005
e-ISSN
1791-7530
Volume of the periodical
44
Issue of the periodical within the volume
1
Country of publishing house
GR - GREECE
Number of pages
12
Pages from-to
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UT code for WoS article
001148798000011
EID of the result in the Scopus database
2-s2.0-85181414246