Re: Laura Elst, Gino Philips, Kaat Vandermaesen, et al. Single-cell Atlas of Penile Cancer Reveals TP53 Mutations as a Driver of an Aggressive Phenotype, Irrespective of Human Papillomavirus Status, and Provides Clues for Treatment Personalization. Eur Urol. In press https://doi.org/10.1016/j.eururo.2024.03.038

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F24%3A10001261" target="_blank" >RIV/00064190:_____/24:10001261 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.eururo.2024.07.029" target="_blank" >https://doi.org/10.1016/j.eururo.2024.07.029</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.eururo.2024.07.029" target="_blank" >10.1016/j.eururo.2024.07.029</a>

Result language
angličtina
Original language name
Re: Laura Elst, Gino Philips, Kaat Vandermaesen, et al. Single-cell Atlas of Penile Cancer Reveals TP53 Mutations as a Driver of an Aggressive Phenotype, Irrespective of Human Papillomavirus Status, and Provides Clues for Treatment Personalization. Eur Urol. In press https://doi.org/10.1016/j.eururo.2024.03.038
Original language description
Penile squamous cell carcinoma (pSCC) is a rare genitourinary tumor associated with poorer prognosis in comparison to more common urological cancers. Elst and colleagues report on a novel single-cell RNA sequencing analysis that identified TP53 mutations as a crucial marker of aggressive cancer, independent of human papillomavirus (HPV) status. TP53-mutated pSCCs exhibited epithelial-mesenchymal transition (EMT) transcriptional signatures. Morphologically, this was evident as high tumor budding, which is a well-known indicator of metastasis and poor prognosis across various cancers. Our group recently described the negative prognostic impact of tumor budding, mutated p53 expression profiles (n = 152), and high tumor mutational burden (n = 136) in relatively large cohorts.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30217 - Urology and nephrology

Project
<a href="/en/project/NU21J-03-00019" target="_blank" >NU21J-03-00019: The prognostic predictive markers in penile carcinoma: a molecular and morphological study.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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