Plasma miR-122-5p and miR-142-5p and their role in chemoresistance of patients with colon cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F24%3A10001275" target="_blank" >RIV/00064190:_____/24:10001275 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1093/mutage/geae023" target="_blank" >https://doi.org/10.1093/mutage/geae023</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/mutage/geae023" target="_blank" >10.1093/mutage/geae023</a>

Result language
angličtina
Original language name
Plasma miR-122-5p and miR-142-5p and their role in chemoresistance of patients with colon cancer
Original language description
Chemoresistance represents a major issue affecting cancer therapy efficacy. Because microRNAs (miRNAs) regulate gene expression on multiple levels, their role in chemoresistance development is reasonably certain. In our previous study, miR-122-5p and miR-142-5p were identified as diagnostic, prognostic, and predictive biomarkers for primary and metastatic rectal cancer. The aim of the present study was to investigate whether these miRNAs can also reflect the disease course of patients with colon cancer (CC). Further, we focused on a deeper understanding of their involvement in 5-fluorouracil (5-FU) chemoresistance development.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30101 - Human genetics

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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