GLYCOSAMINOGLYCAN POLYSULFURIC ACID (GAGPS) IN OSTEOARTHRITIS OF THE KNEE

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F95%3A%230000955" target="_blank" >RIV/00064190:_____/95:#0000955 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/S1063-4584(05)80034-2" target="_blank" >http://dx.doi.org/10.1016/S1063-4584(05)80034-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/S1063-4584(05)80034-2" target="_blank" >10.1016/S1063-4584(05)80034-2</a>

Result language
angličtina
Original language name
GLYCOSAMINOGLYCAN POLYSULFURIC ACID (GAGPS) IN OSTEOARTHRITIS OF THE KNEE
Original language description
We studied the efficacy and tolerability of glycosaminoglycan polysulfuric acid (GAGPS) in 80 patients with osteoarthritis (OA) of the knee. Patients received two series of five intra-articular injections, at 1-week intervals, of 25 mg (0.5 ml) GAGPS into the knee in a double-blind, parallel, randomized, placebo-controlled trial. There was an immediate decrease in pain after the injections of 43% with GAGPS and 33% with placebo (P = 0.047) (Jezek pain index). Pain relief of GAGPS vs placebo was not different at other intervals (10, 14, 22, 26 weeks after start of treatment). At 6 weeks the Lequesne index decreased 20% after GAGPS and 9% after placebo (P = 0.17). At 10 weeks the Lequesne index decreased 24% after GAGPS and 13% after placebo (P = 0.20).The decrease in Lequesne index at 14 weeks was 31% after GAGPS and 15% after placebo (P = 0.06). The other measured parameters tended to be more favorably influenced by GAGPS than placebo. GAGPS was well tolerated, with associated mild ad
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Publication year
1995
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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