Prevalence of HHV-6 Integrated Chromosomally Among Children Treated for Acute Lymphoblastic or Myeloid Leukemia in the Czech Republic
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F09%3A5430" target="_blank" >RIV/00064203:_____/09:5430 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/09:5430 RIV/65269705:_____/09:#0000852
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Prevalence of HHV-6 Integrated Chromosomally Among Children Treated for Acute Lymphoblastic or Myeloid Leukemia in the Czech Republic
Original language description
Chromosomal integration (CI) of human herpesvirus 6 (HHV-6) is relatively rare new phenomenon. Samples from 339 pediatric patients treated for leukemia in the Czech Republic between the years 1995?2007 were tested retrospectively for HHV-6 DNA quantity,normalized to 100,000 human genome quivalents and expressed in normalised viral copies (NVCs). HHV-6 DNA was detected in 107 samples from 91 patients (26.8%). In majority of samples (99) median 1.84 NVCs was detected. A high viral load about 100,000 NVCswas detected in 5 patients (1.5%; median 140,150 NVCs), confirmed as CI-HHV-6 carriers by a detection of HHV-6 DNA in hair follicles/nails. In all but one patient HHV-6 variant B was detected. None patient with CI-HHV-6 had complications attributable toHHV-6 infection. Prevalence of CI-HHV-6 in childhood leukemia does not differ from other patients or healthy populations.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Medical Virology
ISSN
0146-6615
e-ISSN
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Volume of the periodical
81
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
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UT code for WoS article
000262095300008
EID of the result in the Scopus database
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