Prevalence of chromosomally integrated HHV-6 in patients with malignant disease and healthy donors in the Czech Republic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10193809" target="_blank" >RIV/00216208:11130/13:10193809 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/13:10193809 RIV/00023736:_____/13:00009671 RIV/00216208:11120/13:43907104

Result on the web

<a href="http://dx.doi.org/10.1007/s12223-012-0180-z" target="_blank" >http://dx.doi.org/10.1007/s12223-012-0180-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12223-012-0180-z" target="_blank" >10.1007/s12223-012-0180-z</a>

Result language

angličtina

Original language name

Prevalence of chromosomally integrated HHV-6 in patients with malignant disease and healthy donors in the Czech Republic

Original language description

During the prospective surveillance, we tested 812 patients treated for malignant disease. HHV-6 DNA was detected in 86 obtained screening blood samples. High HHV-6 DNA positivity was detected in nine samples from three children and six adults (median 93,827 NVCs; range 27,530-271,064 NVCs), while in the rest of the patients, we detected lower HHV-6 DNA levels (median 12.9 NVCs; range 1.1-1,430 NVCs). Low-level HHV-6 DNA positivity was observed in 51 children and 26 adults. In all nine patients with high HHV-6 DNA positivity, we subsequently confirmed Ci-HHV-6 by detection of HHV-6 DNA in the nails (median 59,636 NVCs; range 35,789-130,133 NVCs). In seven of them, we detected HHV-6 A, while in the rest HHV-6 B. During the surveillance two patients withacute myeloid leukaemia (AML) deceased due to progression of the primary disease, one underwent allogeneic haematopoietic stem cell transplantation (HSCT) for AML and the rest of the patients with Ci-HHV-6 successfully finished the chemo

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

<a href="/en/project/NS9907" target="_blank" >NS9907: Prevalence a biological consequencies of Human Herpesvirus 6 (HHV6) chromosomal integration in paediatric and adult patients treated with malignant disease</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Microbiologica

ISSN

0015-5632

e-ISSN

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Volume of the periodical

58

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

87-90

UT code for WoS article

000312496800014

EID of the result in the Scopus database

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