Expansion of T helper type 17 lymphocytes in patients with chronic granulomatous disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F11%3A7091" target="_blank" >RIV/00064203:_____/11:7091 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/11:7091

Result on the web

<a href="http://www.ncbi.nlm.nih.gov/pubmed/21910722" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/21910722</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Expansion of T helper type 17 lymphocytes in patients with chronic granulomatous disease

Original language description

Hyper-immunoglobulin (Ig) E syndrome (HIES) is a primary immunodeficiency associated with mutations in STAT3 resulting in impaired development of T helper type 17 (Th17) lymphocytes. HIES patients with a reduced frequency of Th17 cells present with infections caused by Staphylococcus aureus and/or Candida strains. The same spectrum of pathogens is present in patients with chronic granulomatous disease (CGD). We analysed the characteristics of the Th17 compartment in HIES and CGD. HIES patients showed very low numbers of Th17 cells. By contrast, the frequency of Th17 cells and production of Th17-derived cytokines was significantly higher among CGD patients when compared to both control samples and HIES. Naive CD4(+) cells in CGD patients had a normal capacity to differentiate into IL-17-producing cells and the numbers of Th17 cells in the CGD patients normalized following successful bone marrow transplantation. Our findings complement recent data on the importance of Th17 cells for elim

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

<a href="/en/project/NS10489" target="_blank" >NS10489: Functional characteristics of circulating dendritic cells in patients with X-linked agammaglobulinemia</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical and Experimental Immunology

ISSN

0009-9104

e-ISSN

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Volume of the periodical

166

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

26-33

UT code for WoS article

000294913700003

EID of the result in the Scopus database

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