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Poly I: C-activated dendritic cells that were generated in CellGro for use in cancer immunotherapy trials

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F11%3A7266" target="_blank" >RIV/00064203:_____/11:7266 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11130/11:7266

  • Result on the web

    <a href="http://www.translational-medicine.com/content/pdf/1479-5876-9-223.pdf" target="_blank" >http://www.translational-medicine.com/content/pdf/1479-5876-9-223.pdf</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Poly I: C-activated dendritic cells that were generated in CellGro for use in cancer immunotherapy trials

  • Original language description

    Background: For clinical applications, dendritic cells (DCs) need to be generated using GMP-approved reagents. In this study, we tested the characteristics of DCs generated in two clinical grade culture media and activated by three maturation stimuli, Poly I: C, LPS and the mixture of proinflammatory cytokines in order to identify the optimal combination of culture media and activation stimulus for the clinical use. Method: We tested DCs generation using two GMP-certified culture media, CellGro and RPMI+5% human AB serum and evaluated DCs morphology, viability and capapability to mature. We tested three maturation stimuli, PolyI:C, LPS and the mixture of proinflammatory cytokines consisting of IL-1, IL-6, TNF and prostaglandin E2. We evaluated the capacity of activated DCs to induce antigen-specific T cells and regulatory T lymphocytes. Results: Cell culture in CellGro resulted in a higher yield of immature DCs resulting from increased number of adherent monocytes. DCs that were genera

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EC - Immunology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NT11559" target="_blank" >NT11559: Dendritic cell based cancer immunotherapy of prostate cancer Phase I/II clinical trial</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Translational Medicine

  • ISSN

    1479-5876

  • e-ISSN

  • Volume of the periodical

    9

  • Issue of the periodical within the volume

    223

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    10

  • Pages from-to

    1-10

  • UT code for WoS article

    000299108200001

  • EID of the result in the Scopus database