Cribriform adenocarcinoma of minor salivary glands may express galectin-3, cytokeratin 19, and HBME-1 and contains polymorphisms of RET and H-RAS proto-oncogenes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A8140" target="_blank" >RIV/00064203:_____/12:8140 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/12:8140 RIV/00216208:11150/12:10124610 RIV/00216208:11140/12:10124610 RIV/00023761:_____/12:#0000224 RIV/00179906:_____/12:10124610

Result on the web

<a href="http://dx.doi.org/10.1007/s00428-012-1320-1" target="_blank" >http://dx.doi.org/10.1007/s00428-012-1320-1</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Cribriform adenocarcinoma of minor salivary glands may express galectin-3, cytokeratin 19, and HBME-1 and contains polymorphisms of RET and H-RAS proto-oncogenes

Original language description

The aim of the study was to further elucidate the immunohistochemical and genetic characteristics of cribriform adenocarcinoma of minor salivary glands (CAMSG). The study comprised five CAMSG from two males and three females, aged 21-72 years. Four tumors were localized at the base of tongue and one in the floor of mouth. At the time of diagnosis, four tumors had metastasised to regional lymph nodes. After tumor resection, two patients were treated by radiotherapy and one by chemoradiotherapy. During the follow-up (median 14 months), two patients developed lymph node metastasis. Microscopically, all tumors showed cribriform, papillary, follicular, and microcystic growth patterns. The tumor cells displayed vesicular nuclei with intranuclear grooves. Immunohistochemically, all tumors showed expression of cytokeratin (CK) 7, CK8, CK18, vimentin, smooth muscle actin, calponin, S-100 protein, and p16 protein. In addition, we observed expression of galectin-3, CK19, and HBME-1, but not of th

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/NT13901" target="_blank" >NT13901: Study of the Genetic Alterations in Thyroid Cancer</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Virchows Archiv

ISSN

0945-6317

e-ISSN

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Volume of the periodical

461

Issue of the periodical within the volume

5

Country of publishing house

DE - GERMANY

Number of pages

10

Pages from-to

531-540

UT code for WoS article

000310537200007

EID of the result in the Scopus database

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