Closed tube method for rapid screening of IL28B polymorphisms involved in response to hepatitis C treatment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A8159" target="_blank" >RIV/00064203:_____/12:8159 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/12:8159

Result on the web

<a href="http://dx.doi.org/10.1016/j.mcp.2012.04.001" target="_blank" >http://dx.doi.org/10.1016/j.mcp.2012.04.001</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Closed tube method for rapid screening of IL28B polymorphisms involved in response to hepatitis C treatment

Original language description

Background & aim: Hepatitis C is a liver disease caused by the hepatitis C virus. Interferon and ribavirin combination therapy has been a standard treatment of chronic hepatitis C. But only about 50% of patients have positive response to treatment and achieve so called sustained virological response. Recent studies indicate association of several single nucleotide polymorphisms near IL28B gene and response of hepatitis C patients to combined interferon/ribavirin treatment. In this study, rapid, specificand cost-effective small amplicon genotyping method for the two clinically important polymorphisms, rs12979860 C > T and rs8099917 T > G, near the IL28B gene is described. Methods: The distribution of genotypes of 181 HCV-uninfected Slovak Caucasians was analyzed using this novel method, based on a real-time melting analysis of the small amplicon. Results and conclusions: The frequency of wild-type (TT) homozygotes for rs8099917 was 66.30%, frequency of heterozygotes (TG) was 30.94% and

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular and Cellular Probes

ISSN

0890-8508

e-ISSN

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Volume of the periodical

26

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

159-163

UT code for WoS article

000305658700003

EID of the result in the Scopus database

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