Deregulation of Gene Expression Induced by Environmental Tobacco Smoke Exposure in Pregnancy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A8210" target="_blank" >RIV/00064203:_____/12:8210 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/12:00382957 RIV/00216208:11130/12:8210 RIV/00023736:_____/12:00010113

Result on the web

<a href="http://dx.doi.org/10.1093/ntr/ntr325" target="_blank" >http://dx.doi.org/10.1093/ntr/ntr325</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Deregulation of Gene Expression Induced by Environmental Tobacco Smoke Exposure in Pregnancy

Original language description

Environmental tobacco smoke (ETS) exposure in pregnant women may have detrimental effects such as spontaneous abortion, lower birth weight, stillbirth, and reduced infant lung function. To extend our knowledge on the molecular effects of tobacco smoke exposure in pregnancy, we analyzed transcriptome alterations in passive smokers (PS) and compared them with those in active smokers (AS). Using Illumina Expression Beadchips with 24,526 transcript probes, gene expression patterns were assayed in placentasfrom PS (N = 25) exposed to ETS throughout pregnancy and nonexposed (NS) counterparts (N = 34) and in cord blood cells from their newborns. ETS exposure was evaluated by questionnaire disclosure and cotinine measurement in maternal and cord blood. A total of 158 genes were significantly deregulated in the placentas of PS compared with NS. These genes were associated with the extracellular matrix, apoptosis, placental function, blood clotting, response to stress, and lipid metabolism. Cor

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FQ - Public health system, social medicine

OECD FORD branch

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Project

<a href="/en/project/2B06088" target="_blank" >2B06088: Application of toxicogenomics to study mechanisms of the action of environmental pollutants on human health.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nicotine & Tobacco Research

ISSN

1462-2203

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

9

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

1073-1082

UT code for WoS article

000308545800010

EID of the result in the Scopus database

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