Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A8225" target="_blank" >RIV/00064203:_____/12:8225 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/12:00062583 RIV/00216208:11130/12:8225 RIV/65269705:_____/12:#0001716
Result on the web
<a href="http://dx.doi.org/10.1016/j.exphem.2012.06.011" target="_blank" >http://dx.doi.org/10.1016/j.exphem.2012.06.011</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation
Original language description
Acute graft-vs-host disease (aGVHD) is a frequent, life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Despite that, there are no reliable molecular markers reflecting the onset or clinical course of aGVHD.We performed a pilot study on gene expression profiling in peripheral blood mononuclear cells taken from 15 patients with hematological malignancies who underwent allo-HSCT and developed aGVHD. Based on survival rates after aGVHD, patients were dividedinto two groups-favorable (all patients alive; median follow-up 40 months) vs unfavorable group (all patients died; median survival 2 months). Two-hundred and eighty genes differentially expressed between these two groups were identified; among them, genes responsible for cytokine signaling, inflammatory response, and regulation of cell cycle were over-represented; interleukin-8, GOS2, ANXA3, and NR4A2 were upregulated in the unfavorable group, CDKN1C was downregulated in the same group.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Experimental Hematology
ISSN
0301-472X
e-ISSN
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Volume of the periodical
40
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
899-905
UT code for WoS article
000310182400004
EID of the result in the Scopus database
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